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Isis Vestige Part A
Location: Cathedral of the Sacred Blood – Inner Tower
From the Inner Tower mistle, take the northeastern path (left with the locked feathered door behind you) across a walkway to end up in a room with just a ladder. Take the ladder to the top then go left (northeast) and head across the walkway. This will bring you to an open room with no roof and a giant hole in the middle. Take care of the two enemies here then drop down into the hole. Now you should be on a circular platform with multiple doorways. Take the northern doorway and drop down on the walkway below. The vestige will be straight ahead guarded by an enemy.
Isis Vestige Part B
Location: Cathedral of the Sacred Blood – Cathedral of the Sacred Blood Entrance
From the entrance mistle, head north taking the stairs down and follow the path to the big circle platform. Once on the platform, take the left path (west), follow it straight and then take the spiraling stairs to the second level. Keep following the path forward until you reach a doorway (this doorway is locked until you unlock it from the other side). Head through the doorway and exit through the doorway straight ahead on the other side of the room. Keep following the path forward until you come to a split. Take a left and keep following the path (eventually you will come to stairs leading down). At the bottom of the stairs, turn right and follow the path forward to arrive at a circular room containing the vestige. Entering the room will trigger a Trial of Blood.
Isis Vestige Part C
Location: Cathedral of the Sacred Blood – Outlook Tower
From the Outlook Tower mistle, head down the winding steps and follow the walkway (going up a long flight of stairs) ending up at a big circle platform with a lone enemy on it. Take the right (and only other) walkway to arrive at another circular platform. Take the ladder on the other side of the platform down to a ledge with another ladder. Take the ladder down to another ledge with an entryway into another circular room. This vestige will be located here.
Isis Vestige Part D
Location: Cathedral of the Sacred Blood – Cathedral Front
This vestige is obtained as part of the story.
Isis Vestige Part E
Location: Cathedral of the Sacred Blood – Inner Tower
From the Inner Tower mistle, take the northeastern path (left with the locked feathered door behind you) across a walkway to end up in a room with just a ladder. Take the ladder to the top then turn right and drop down onto the walkway below. Head into the circular room and take the spiraling steps in the middle of the room down a level. Exit the stairwell and take a left. Pass through the doorway ahead on the right to come to a walkway. At the end of the walkway, there will be a circular room with a small hole in the middle. Drop down the center of that hole to land on the circular platform containing the vestige.
