Welcome to NGB’s Asclepius Vestige Guide! In this walkthrough, we’ll cover every location of the Asclepius Vestige parts, explain how to restore them with Io, and highlight the Gifts you’ll unlock along the way. Whether you’re chasing completion for the Mender of Minds trophy or aiming for the true ending, this guide ensures you won’t miss a single vestige.
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Asclepius Vestige Guide
Vestige Parts
Asclepius Vestige Part A
- Location: Depths – Fiery Oblivion
Defeat the Blazing Heretic mini-boss located in the northern part of the map.
Asclepius Vestige Part B
- Location: Depths – Fiery Oblivion
Defeat the Abyssal Doppleganger mini-boss located in the southwestern part of the map.
Asclepius Vestige Part C
- Location: Depths – Celestial Ice Prison
The vestige can be obtained from defeating the Mud Gorger (with the group of moneys that spawn).
Asclepius Vestige Part D
Location: Depths – Celestial Ice Prison
The vestige can be obtained from defeating Argent Wolf Berserker.
Asclepius Vestige Part E
- Location: Sealed Depths – Eternal Abyss
Defeat the Dusty Cloud Bandit to receive this vestige.
Asclepius Vestige Part F
- Location: Sealed Depths – Eternal Abyss
Defeat the Queen’s Vanguard Puppet to receive this vestige.
Asclepius Vestige Part G
Location: Crypt Spire – Upper Level
From the Crypt Spire mistle, head north, passing the areas where you fought the Blade Bearer, Cannoneer, and Juzo Mido. This will lead you to a long hallway with lights lining both sides. Head through that hallway and make a left at the end, going down a side set of stairs. (There is another set of stairs that keeps leading north. Don’t go that way!) The vestige will be at the bottom of the steps in the middle of the floor.
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